2003 Chevy Tahoe 5.3L 4WD - Cylinder #1 Misfire - Check Engine Light?

On my Tahoe there is a continued engine light I have read the code and it informs me that there is a misfire on Cylinder #1. Check engine light is usually continuous but often flashes. Has anyone ever had a similar problem? I have replaced the spark plug, the coil and the plug wire. Is the next step replacing the fuel injector? I have used fuel injector cleaners multiple times.